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Langerhans cell histiocytosis

Langerhans cell histiocytosis

  • It is classified into three clinical forms:
    • Solitary eosinophilic granuloma: local (usually in older children and young adults)
    • Hand-Schuller-Christian disease: chronic, widespread
    • Leterrer-Siwe disease: malignant, acute, widespread (children under 3 years old).
  • The borders of the lesion are usually well defined but not corticated (punched out). Most often the lesions are multiple with irregular borders and cortical infiltration is observed.
  • Adjacent teeth become loose (“floating”)
  • No expansion of surrounding bone.

Differential diagnosis


The second panoramic image was taken six months later. The first time the disease was misdiagnosed and treated as periodontitis

Langerhans cell histiocytosis in the mandible.

Langerhans cell histiocytosis in the maxilla.(same patient as above).

Langerhans cell histiocytosis in upper and lower jaw.