Multiple myeloma

Multiple myeloma

Characteristics
  • It is a multifocal malignancy of the plasma cells.
  • It is the most common malignancy of bone in adults. It occurs between the ages 35-70 with a mean age of 60 years.
  • Lesion margins are usually well-defined but not corticated (punched-out). Some lesions may appear ragged and infiltrative. As the disease progresses the multiple radiolucencies may form a large single lesion with ill defined borders and cortex infiltration.
  • Multiple round radiolucencies in the skull and jaws (more often in the mandible).
  • Symptoms and signs include pain, swelling, paraesthesia, soft tissue mass and tooth mobility. Large lesions can lead to pathological fractures.

Cases

Multiple myeloma

Multiple myeloma

Courtesy of Prof. CJ. Nortje, Univ. of Stellenbosch, S. Africa.