Langerhans cell histiocytosis

Features

  • It is caused by the abnormal proliferation of Langerhans cells.
  • It is classified in three clinical forms:
    • Solitary eosinophilic granuloma: localized (most often in older children and young adults).
    • Hand-Schuller-Christian disease: chronic, wide-spread.
    • Leterrer-Siwe disease: malignant, acute, wide-spread (children under than 3 years old).
  • Lesion margins are usually well-defined but not corticated (punched-out).
  • The adjacent teeth become loose (floating)
  • No expansion of the surrounding bone.

Differential diagnosis

Cases

Case 1

The second panoramic image was taken six months later. The first time the disease was misdiagnosed and treated as periodontitis

Case 2

Langerhans cell histiocytosis in the mandible.

Case 3

Langerhans cell histiocytosis in the maxilla.(same patient as above).

Case 4


Langerhans cell histiocytosis in the maxilla.(same patient as above).