• Malignant neoplasms of haemopoietic stem cells.
  • Acute cases are usually seen in children and chronic cases in those of 25 to 60 years old.
  • Signs and symptoms include: splinomegaly, bleeding, bone pain, gingival inflammation, loose teeth, ulceration.
  • Radiographic changes are more common in the acute type: Premature loss of teeth. Loss of lamina dura. Periapical radiolucency similar to periodontal disease. Single layer of periosteal new bone formation on the inferior border of the mandible. Multiple punched-out radiolucencies.

Differential diagnosis


Courtesy of Prof. CJ. Nortje, Univ. of Stellenbosch, S. Africa.
Panoramic images before and after treatment