Langerhans cell histiocytosis


  • It is caused by the abnormal proliferation of Langerhans cells.
  • It is classified in three clinical forms:
    • Solitary eosinophilic granuloma: localized (most often in older children and young adults).
    • Hand-Schuller-Christian disease: chronic, wide-spread.
    • Leterrer-Siwe disease: malignant, acute, wide-spread (children under than 3 years old).
  • Lesion margins are usually well-defined but not corticated (punched-out).
  • The adjacent teeth become loose (floating)
  • No expansion of the surrounding bone.

Differential diagnosis


The second panoramic image was taken six months later. The first time the disease was misdiagnosed and treated as periodontitis

Langerhans cell histiocytosis in the mandible.

Langerhans cell histiocytosis in the maxilla.(same patient as above).

Langerhans cell histiocytosis in upper and lower jaw.